Virtual meeting: Mass Spectrometry at Regeneron

About the meeting:

Sep 26 (Thu), 2 pm ~ 4 pm

To join the video meeting, click this link: 

https://meet.google.com/vah-kogt-fqu

Otherwise, to join by phone, dial +1 336-790-7158 and enter this PIN: 166 072 242#

To view more phone numbers, click this link: https://tel.meet/vah-kogt-fqu?hs=5

About the speakers:

Bojie Zhang: My Journey with Mass Spectrometry - Protein Footprinting and Epitope Mapping for Higher-Order-Structure Elucidation (~45 min)

Bojie Zhang is a Principal Scientist at Regeneron Pharmaceuticals, where he is instrumental in supporting discovery of therapeutic antibodies with mass spectrometry techniques. Bojie specializes in hydrogen-deuterium exchange for epitope mapping, lipidomics, biomarker quantitation, and label-free proteomics. Prior to his work, Bojie earned his PhD from Washington University in St. Louis in 2019, where he conducted research with major focus in protein footrpinting by Fast Photochemical Oxidation of Proteins (FPOP).

Darshit Shah: Leveraging Orbitrap Astral Mass Spectrometry for High- Sensitivity Immunopeptidomics: Insights from IM-9 Cells (~45 min)

Darshit Shah is a seasoned professional in the field of Biotechnology, currently serving as a Senior Scientist at Regeneron Pharmaceutical Inc. for the past 12 years. He holds a Master's degree from The University of Texas at San Antonio. Darshit has a strong background in establishing, optimizing, and performing HLA peptidome analysis related to various cancers and viral targets. His expertise lies in using both discovery and targeted approaches to reveal candidates for peptide-based immunotherapy. At Regeneron, Darshit has developed quantitative assays for immunopeptidomes using Mass Spectrometry and has created workflows to analyze immunopeptidomes for cell lines, xenografts, and patient tumors. He is also proficient in designing proteomics experiments to analyze genomics profiling studies (RNA-seq) to support drug target and biomarker identification. His innovative approach led him to develop a novel, efficient high-throughput biomarker discovery method utilizing Mass Spectrometry. He has also designed proteomics experiments to compare and contrast genomics profiling studies (RNA-seq) and has performed affinity-purification coupled to mass spectrometry (AP-MS) for ligand fishing experiments. Darshit's work in quantitative proteomics has been instrumental in identifying biomarkers in serum. He has also identified HLA presented peptides to design patient-based therapy. His extensive knowledge and innovative approach make him a valuable asset in the field of Biotechnology and a key contributor to the success of Regeneron Pharmaceutical Inc.